KLF1 Mutations Are Not Common in Israel but Can Explain Occasional Cases of Elevated HbA2 or Very Elevated Fetal Hemoglobin
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چکیده
منابع مشابه
Homozygous delta-beta Thalassemia in a Child: a Rare Cause of Elevated Fetal Hemoglobin
Abstract Background Delta beta (δβ) thalassemia is an unusual variant of thalassemia with elevated level of fetal hemoglobin (HbF). Homozygous patients of this disorder, unlike β-thalassemia, show mild anemia. Only few cases of δβ-thalassemia have been reported from India in the available indexed English literature. Case presentation A four-year old male child was evaluated for recent-onset...
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A persistent elevation of the fetal hemoglobin in the low-density, reticulocyte-rich cell frac(Hgb F) level (5%-15%) was observed in a tion. In contrast, the highest Hgb F levels were 22-yr-old white male with paroxysmal nocfound in the high-density, reticulocyte-poor turnal hemoglobinuria (PNH). Acid treatment fraction. Further evidence for the segregation of the peripheral smear (Betke-Kleiha...
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In vivo microcracks in cortical bone are typically observed within more highly mineralized interstitial tissue, but postmortem investigations are inherently limited to cracks that did not lead to fracture which may be misleading with respect to understanding fracture mechanisms. We hypothesized that the one fatigue microcrack which initiates fracture is located spatially adjacent to elevated in...
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To the Editor Panyasai et al1 point out an important problem with the measurement of hemoglobin (Hb) A2. By comparing 11 cases of Hb Hope analyzed by capillary electrophoresis (CE) and high-performance liquid chromatography (HPLC; Bio-Rad β-Thalassemia Short Program, Bio-Rad, Hercules, CA), they document a much greater increase in the HbA2 value measured by CE than by HPLC. They also point out ...
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ژورنال
عنوان ژورنال: Blood
سال: 2018
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2018-99-113903